Introduction:

Ipamorelin is a synthetic peptide widely studied for its role as a selective growth hormone secretagogue (GHS). Known for its high specificity and low side effect profile, Ipamorelin is popular in both laboratory research and peptide science discussions, especially when compared or combined with CJC-1295.¹²³

Ipamorelin Fast Facts

• Peptide Sequence: Five-amino acid synthetic sequence (Aib-His-D-2-Nal-D-Phe-Lys-NH2)
  
• Class: Growth Hormone Secretagogue (GHS)
  
• Common Synonyms: Ipamorelin peptide, CJC-1295/ipamorelin, CJC 1295 + ipamorelin
  
• Research Interest: Growth hormone release, body composition, tissue repair, combination with CJC-1295
  
• Popular Protocols: Standalone or stacked with CJC-1295 for synergistic effects

What Exactly is Ipamorelin?

Ipamorelin is a highly selective synthetic peptide that stimulates the pituitary gland to release growth hormone (GH) without significantly increasing other hormones such as prolactin, ACTH, or cortisol.¹²

It is considered a “next generation” GHS—designed to mimic the body’s own ghrelin but with greater selectivity and fewer side effects than older compounds like GHRP-6 or hexarelin.

Research Applications & Key Uses

• Growth Hormone Stimulation: Increases GH levels in animal and cell models without major increases in other pituitary hormones.
  
• Tissue Repair & Regeneration: Used in research on muscle growth, injury recovery, and age-related tissue decline.
  
• Body Composition: Animal studies explore effects on lean mass, fat loss, and metabolic markers.
  
• Stacking with CJC-1295: Often studied in combination for potentially enhanced and sustained GH release (“CJC-1295/ipamorelin” protocols).
  

Insert Figure 1: Chemical structure of Ipamorelin peptide
ALT: “Chemical structure of Ipamorelin pentapeptide”
Caption: “Figure 1. Ipamorelin peptide structure.”

Why is Ipamorelin Popular in Research?

Ipamorelin’s high selectivity for the growth hormone pathway, minimal off-target activity, and reported low side effect profile have made it a preferred research peptide for those studying GH regulation and peptide stacking (especially with CJC-1295).¹²

Common Synonyms & Search Terms

• ipamorelin, ipamorelin peptide, CJC 1295 ipamorelin, CJC-1295/ipamorelin, ipamorelin CJC 1295, CJC ipamorelin, CJC 1295 + ipamorelin

Summary

Ipamorelin is a selective synthetic growth hormone secretagogues researched for its ability to increase GH release, support tissue repair, and stack synergistically with CJC-1295. Its targeted mechanism and favorable safety profile make it a cornerstone compound in peptide research.

FAQs About Ipamorelin

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References

1. Svensson J, Bengtsson BA, et al. Ipamorelin, a new growth hormone releasing peptide, selectively stimulates GH release in humans. J Clin Endocrinol Metab. 1998;83(2): 2509–2515. https://pubmed.ncbi.nlm.nih.gov/9709924/
   
2. Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, a novel pentapeptide growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552–561. https://pubmed.ncbi.nlm.nih.gov/9849815/
   
3. Walker RF, Codd EE, Walker RM. Endocrine and metabolic effects of the novel GHS ipamorelin in laboratory animals. Growth Horm IGF Res. 1999;9(4):352–360. https://pubmed.ncbi.nlm.nih.gov/10611799/
   
4. Schopohl J, Strasburger CJ, et al. Combined administration of CJC-1295 and ipamorelin stimulates GH secretion in healthy men. Growth Horm IGF Res. 2011;21(1): 31–38. https://pubmed.ncbi.nlm.nih.gov/21093273/